Despite his family’s baffling generations-old ban on music, Miguel dreams of becoming an accomplished musician like his idol, Ernesto de la Cruz. Desperate to prove his talent, Miguel finds himself in the stunning and colorful Land of the Dead following a mysterious chain of events. Along the way, he meets charming trickster Hector, and together, they set off on an extraordinary journey to unlock the real story behind Miguel's family history.
Though she can spin wild tales of passionate romance, novelist Joan Wilder has no life of her own. Then one day adventure comes her way in the form of a mysterious package. It turns out that the parcel is the ransom she'll need to free her abducted sister, so Joan flies to South America to hand it over. But she gets on the wrong bus and winds up hopelessly stranded in the jungle.
Aging outlaw Pike Bishop prepares to retire after one final robbery. Joined by his gang, which includes Dutch Engstrom and brothers Lyle and Tector Gorch, Bishop discovers the heist is a setup orchestrated in part by his old partner, Deke Thornton. As the remaining gang takes refuge in Mexican territory, Thornton trails them, resulting in fierce gunfights with plenty of casualties.