Crash! (1976)

"An Occult Object Takes Possession of a Driverless Car and Causes One Spectacular Crash After Another Until Fifty Cars Are Pounded Into a Mass of Twisted Metal"

After a professor is crippled in a car accident, he blames his wife for the ordeal and attempts to have her killed using the same means. Now hospitalized with amnesia, she appears to be protected by a tiny voodoo trinket that she still clutches in her hand, which possesses her car and other objects, causing mayhem throughout the city.